Detection of recurrence in childhood solid tumors

Cancer. 2005 Mar 15;103(6):1274-9. doi: 10.1002/cncr.20896.

Abstract

Background: Frequent follow-up and regular investigation are routine in pediatric oncology. However, there is little evidence regarding their value in the detection of recurrent disease.

Methods: The authors carried out a retrospective study of the follow-up of 186 children with solid tumors who were diagnosed between 1992 and 1996. The numbers of clinic visits, follow-up investigations, and (if appropriate) the mode of recurrence detection were recorded.

Results: The mean follow-up was 5.9 years. During this time, 37 recurrences were detected, symptomatically in 54% of patients, by routine investigation in 30% of patients, and at routine clinic appointment in 16% of patients. It was calculated that routine magnetic resonance imaging detected 1 recurrence for every 42 scans performed, routine computed tomography detected 1 recurrence for every 129 scans performed, and routine chest radiography detected 1 recurrence for every 257 films.

Conclusions: The current results raise questions regarding the usefulness of such follow-up in children with solid tumors.

Publication types

  • Comparative Study

MeSH terms

  • Age Distribution
  • Child
  • Child, Preschool
  • Cohort Studies
  • Disease-Free Survival
  • Female
  • Humans
  • Incidence
  • Infant
  • Magnetic Resonance Imaging
  • Male
  • Neoplasm Invasiveness / pathology*
  • Neoplasm Recurrence, Local / epidemiology*
  • Neoplasm Recurrence, Local / pathology*
  • Neoplasm Staging
  • Neoplasms / epidemiology*
  • Neoplasms / pathology*
  • Retrospective Studies
  • Risk Assessment
  • Sex Distribution
  • Survival Analysis
  • Tomography, X-Ray Computed