Aurantosides G, H, and I: three new tetramic acid glycosides from a Papua New Guinea Theonella swinhoei

J Nat Prod. 2005 Jan;68(1):104-7. doi: 10.1021/np049721s.

Abstract

Aurantosides G-I (1-3) have been isolated from the lithistid sponge Theonella swinhoei from Papua New Guinea. Their structures were established by spectroscopic and chemical methods. Compounds 1-3 represent new monochloropentaenoyl tetramic acids with mono-, di-, and tri-N-saccharide substituents, respectively. Aurantosides G-I (1-3) failed to show any significant cytotoxicity against the human colon tumor cell line HCT-116.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Drug Screening Assays, Antitumor
  • Glycosides / chemistry
  • Glycosides / isolation & purification*
  • Glycosides / pharmacology
  • Humans
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Papua New Guinea
  • Porifera / chemistry*
  • Pyrrolidinones / chemistry
  • Pyrrolidinones / isolation & purification*
  • Pyrrolidinones / pharmacology
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Glycosides
  • Pyrrolidinones
  • aurantoside G
  • aurantoside H
  • aurantoside I