Peyer's patch dendritic cells capturing oral antigen interact with antigen-specific T cells and induce gut-homing CD4(+)CD25(+) regulatory T cells in Peyer's patches

Ann N Y Acad Sci. 2004 Dec:1029:366-70. doi: 10.1196/annals.1309.020.

Abstract

Antigen-specific naive T cells accumulated in Peyer's patches only after the feeding of antigen. DCs that captured oral antigen interacted with these T cells in the IFR of PP. Some of these T cells acquired a similar phenotype to CD4(+) CD25(+) regulatory T cells and CCR9(+) gut-homing T cells.

MeSH terms

  • Administration, Oral
  • Animals
  • Antigens / immunology
  • CD4 Antigens / immunology*
  • CD4-Positive T-Lymphocytes / immunology*
  • Immunity, Mucosal*
  • Mice
  • Mice, Inbred BALB C
  • Mice, Transgenic
  • Ovalbumin / administration & dosage
  • Ovalbumin / genetics
  • Ovalbumin / immunology
  • Peyer's Patches / immunology*
  • Receptors, Antigen, T-Cell / immunology
  • Receptors, Interleukin-2 / immunology*

Substances

  • Antigens
  • CD4 Antigens
  • Receptors, Antigen, T-Cell
  • Receptors, Interleukin-2
  • Ovalbumin