To B or not to B: PIP2 answers the question

Diana Murray; Barry Honig

doi:10.1016/j.devcel.2005.01.002

To B or not to B: PIP2 answers the question

Dev Cell. 2005 Feb;8(2):138-9. doi: 10.1016/j.devcel.2005.01.002.

Authors

Diana Murray¹, Barry Honig

Affiliation

¹ Department of Microbiology and Immunology and,Institute of Computational Biomedicine, Weill Medical College of Cornell University, New York, New York 10021, USA.

PMID: 15691756
DOI: 10.1016/j.devcel.2005.01.002

Abstract

In a recent issue of Molecular Cell, Papayannopoulos et al. (2005) show that N-WASP activation of actin-related protein2/3 (Arp2/3) is ultrasensitive to PI(4,5)P(2) concentration. We discuss how interactions between basic regions in proteins and negatively charged membranes can produce sharp on-off switches that may regulate biological activity.

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Comment

MeSH terms

Actin-Related Protein 2
Actin-Related Protein 3
Binding Sites
Cytoskeletal Proteins / metabolism
Kinetics
Models, Molecular
Nerve Tissue Proteins / chemistry*
Nerve Tissue Proteins / metabolism*
Phosphatidylinositol 4,5-Diphosphate / metabolism*
Protein Structure, Tertiary
Static Electricity
Wiskott-Aldrich Syndrome Protein, Neuronal

Substances

Actin-Related Protein 2
Actin-Related Protein 3
Cytoskeletal Proteins
Nerve Tissue Proteins
Phosphatidylinositol 4,5-Diphosphate
Wiskott-Aldrich Syndrome Protein, Neuronal