A phase I and pharmacokinetic study of short infusions of UCN-01 in patients with refractory solid tumors

Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):664-71.
No abstract available

Publication types

  • Clinical Trial
  • Clinical Trial, Phase I
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / pharmacokinetics*
  • Dose-Response Relationship, Drug
  • Drug Resistance, Neoplasm
  • Female
  • Humans
  • Infusions, Intravenous
  • Male
  • Maximum Tolerated Dose
  • Middle Aged
  • Neoplasms / metabolism*
  • Neoplasms / pathology
  • Protein Kinase C / antagonists & inhibitors
  • Salvage Therapy
  • Staurosporine / administration & dosage
  • Staurosporine / analogs & derivatives*
  • Staurosporine / pharmacokinetics*
  • Time Factors

Substances

  • Antineoplastic Agents
  • 7-hydroxystaurosporine
  • Protein Kinase C
  • Staurosporine