[Screening for the G1528C mutation in long chain fatty acid oxidation enzyme in Han nationality in Beijing population]

Beijing Da Xue Xue Bao Yi Xue Ban. 2005 Feb 18;37(1):72-4.
[Article in Chinese]

Abstract

Objective: To explore the carrier rate of G1528C mutation in alpha-subunit gene of MTP in Chinese newborns.

Methods: 1 200 cases of cord blood samples were taken in pregnant women with Han nationality in Chinese. PCR-RFLP analysis was conducted for detection of G1528C mutation.

Results: No. G1528C mutations in LCHAD gene were found in these study subjects.

Conclusion: G1528C is probably not the common prevalent mutation in MTP gene in Chinese. Different prevalent mutation between Chinese and Western white people needs further study.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • China / ethnology
  • Female
  • Genetic Testing
  • Humans
  • Infant, Newborn
  • Lipid Metabolism, Inborn Errors / genetics
  • Male
  • Mitochondrial Trifunctional Protein
  • Multienzyme Complexes / genetics*
  • Oxidation-Reduction
  • Point Mutation*
  • Polymerase Chain Reaction
  • Polymorphism, Restriction Fragment Length

Substances

  • Multienzyme Complexes
  • Mitochondrial Trifunctional Protein