Abstract
The current study of 153 subjects with both classic and atypical myeloproliferative disorders suggests that neutrophil polycythemia rubra vera-1 (PRV-1) over-expression is a non-specific feature of clonal myeloproliferation that displays significant correlation with leukocyte alkaline phosphatase score. These observations undermine the utility of the PRV-1 assay as a diagnostic test of additional value.
MeSH terms
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Adult
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Aged
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Alkaline Phosphatase / analysis
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Clinical Enzyme Tests
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Female
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GPI-Linked Proteins
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Humans
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Isoantigens / analysis*
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Isoantigens / genetics
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Male
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Membrane Glycoproteins / analysis*
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Membrane Glycoproteins / genetics
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Middle Aged
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Myeloproliferative Disorders / diagnosis*
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Neutrophils / chemistry
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RNA, Messenger / analysis
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Receptors, Cell Surface / analysis*
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Receptors, Cell Surface / genetics
Substances
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CD177 protein, human
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GPI-Linked Proteins
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Isoantigens
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Membrane Glycoproteins
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RNA, Messenger
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Receptors, Cell Surface
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Alkaline Phosphatase