Neutrophil polycythemia rubra vera-1 expression in classic and atypical myeloproliferative disorders and laboratory correlates

Haematologica. 2005 Mar;90(3):406-8.

Abstract

The current study of 153 subjects with both classic and atypical myeloproliferative disorders suggests that neutrophil polycythemia rubra vera-1 (PRV-1) over-expression is a non-specific feature of clonal myeloproliferation that displays significant correlation with leukocyte alkaline phosphatase score. These observations undermine the utility of the PRV-1 assay as a diagnostic test of additional value.

Publication types

  • Letter

MeSH terms

  • Adult
  • Aged
  • Alkaline Phosphatase / analysis
  • Clinical Enzyme Tests
  • Female
  • GPI-Linked Proteins
  • Humans
  • Isoantigens / analysis*
  • Isoantigens / genetics
  • Male
  • Membrane Glycoproteins / analysis*
  • Membrane Glycoproteins / genetics
  • Middle Aged
  • Myeloproliferative Disorders / diagnosis*
  • Neutrophils / chemistry
  • RNA, Messenger / analysis
  • Receptors, Cell Surface / analysis*
  • Receptors, Cell Surface / genetics

Substances

  • CD177 protein, human
  • GPI-Linked Proteins
  • Isoantigens
  • Membrane Glycoproteins
  • RNA, Messenger
  • Receptors, Cell Surface
  • Alkaline Phosphatase