We report an elderly advanced NSCLC patient effectively treated with vinorelbine on an outpatient basis in cooperation with his family doctor. A 79-year-old man was referred to our hospital for evaluation of a nodular shadow in his right lung. Chest CT scan showed a 2.0 cm tumor shadow in right S1, and small nodular shadows in right S4 and left S5. Neck lymph node biopsy yielded a diagnosis of adenocarcinoma. The clinical stage was IV, and he underwent chemotherapy of vinorelbine 25 mg/m2 on days 1 and 8. The regimen opted for a setup of a schedule, while the dose of vinorelbine and evaluation by CT were done in our hospital. This regimen was well tolerated and suitable. The patient could receive long-term continuation of the chemotherapy medication, and showed improvement in terms of prolongation of life and QOL.