A new antibiotic, antimycin Ag, produced by Streptomyces sp. K01-0031

J Antibiot (Tokyo). 2005 Jan;58(1):74-8. doi: 10.1038/ja.2005.10.

Abstract

A new antimycin group antibiotic, antimycin A9, was isolated from a cultured broth of Streptomyces sp. K01-0031 together with antimycins A3a, A3b, A4, and A7, and flazin methyl ester. Antimycin A9 is the first antimycin having an aromatic 8-acyl residue. It showed potent nematocidal and insecticidal activities against Caenorhabditis elegans and Artemia salina, respectively. It inhibited bovine heart NADH oxidase at nanomolar level like other known antimycins.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Antimycin A / analogs & derivatives*
  • Antimycin A / isolation & purification*
  • Antimycin A / pharmacology
  • Antinematodal Agents / isolation & purification*
  • Antinematodal Agents / pharmacology
  • Artemia / drug effects
  • Caenorhabditis elegans / drug effects
  • Cattle
  • Microbial Sensitivity Tests
  • Multienzyme Complexes / antagonists & inhibitors
  • NADH, NADPH Oxidoreductases / antagonists & inhibitors
  • Streptomyces
  • Structure-Activity Relationship

Substances

  • Anti-Bacterial Agents
  • Antinematodal Agents
  • Multienzyme Complexes
  • antimycin A9
  • Antimycin A
  • NADH oxidase
  • NADH, NADPH Oxidoreductases