Abstract
Synthesis of a polysaccharide adhesin by icaADBC-encoded enzymes is currently the best-understood mechanism of staphylococcal biofilm development. In four methicillin-resistant Staphylococcus aureus isolates, environmental activation of icaADBC did not always correlate with increased biofilm production. Moreover, glucose-mediated biofilm development in these isolates was icaADBC independent. Apparently, an environmentally regulated, ica-independent mechanism(s) of biofilm development exists in S. aureus clinical isolates.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism
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Biofilms / growth & development*
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Gene Expression Regulation, Bacterial*
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Glucose / metabolism
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Humans
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Methicillin Resistance*
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Operon
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Polysaccharides, Bacterial / genetics
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Polysaccharides, Bacterial / metabolism*
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Staphylococcal Infections / microbiology
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Staphylococcus aureus / drug effects
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Staphylococcus aureus / genetics
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Staphylococcus aureus / growth & development*
Substances
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Bacterial Proteins
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Polysaccharides, Bacterial
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polysaccharide intercellular adhesin
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Glucose