Enantioselective syntheses of (+)-xylarenal A and ent-xylarenal A

J Org Chem. 2005 Apr 29;70(9):3749-52. doi: 10.1021/jo0502450.

Abstract

[reaction: see text] The total synthesis of the sesquiterpenoid xylarenal A is reported. This first synthetic entry to an eremophilane terpenoid with an exocyclic vinyl aldehyde unit involves the use of the bicyclic enone (+)-3, which after a gamma-oxidation and alpha'-allylation leads to the formation of the ketone (+)-8. After its acylation, an oxidative cleavage of the allyl side chain followed by alpha-methylenation of the resulting aldehyde gives (+)-xylarenal A (1). The synthesis of (-)-xylarenal A from (-)-3 is also reported. Moreover, the first total synthesis of the trinoreremophilane (+)-1alpha-hydroxyisoondetianone (5) is described.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Fungi / chemistry
  • Indicators and Reagents
  • Molecular Structure
  • Sesquiterpenes / chemical synthesis*
  • Stereoisomerism

Substances

  • Indicators and Reagents
  • Sesquiterpenes
  • xylarenal A