Determinants of spatial and temporal coding by semicircular canal afferents

J Neurophysiol. 2005 May;93(5):2359-70. doi: 10.1152/jn.00533.2004.

Abstract

The vestibular semicircular canals are internal sensors that signal the magnitude, direction, and temporal properties of angular head motion. Fluid mechanics within the 3-canal labyrinth code the direction of movement and integrate angular acceleration stimuli over time. Directional coding is accomplished by decomposition of complex angular accelerations into 3 biomechanical components-one component exciting each of the 3 ampullary organs and associated afferent nerve bundles separately. For low-frequency angular motion stimuli, fluid displacement within each canal is proportional to angular acceleration. At higher frequencies, above the lower corner frequency, real-time integration is accomplished by viscous forces arising from the movement of fluid within the slender lumen of each canal. This results in angular velocity sensitive fluid displacements. Reflecting this, a subset of afferent fibers indeed report angular acceleration to the brain for low frequencies of head movement and report angular velocity for higher frequencies. However, a substantial number of afferent fibers also report angular acceleration, or a signal between acceleration and velocity, even at frequencies where the endolymph displacement is known to follow angular head velocity. These non-velocity-sensitive afferent signals cannot be attributed to canal biomechanics alone. The responses of non-velocity-sensitive cells include a mathematical differentiation (first-order or fractional) imparted by hair-cell and/or afferent complexes. This mathematical differentiation from velocity to acceleration cannot be attributed to hair cell ionic currents, but occurs as a result of the dynamics of synaptic transmission between hair cells and their primary afferent fibers. The evidence for this conclusion is reviewed below.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Afferent Pathways / anatomy & histology
  • Afferent Pathways / physiology
  • Animals
  • Biomechanical Phenomena
  • Hair Cells, Vestibular / physiology
  • Head Movements / physiology
  • Humans
  • Labyrinthine Fluids / physiology
  • Motion Perception / physiology*
  • Neural Networks, Computer
  • Reflex, Vestibulo-Ocular / physiology*
  • Semicircular Canals / cytology
  • Semicircular Canals / physiology*
  • Signal Transduction
  • Space Perception / physiology*
  • Synapses