Gilles de la Tourette syndrome and voluntary movement: a functional MRI study

Psychiatry Res. 2005 Apr 30;138(3):269-72. doi: 10.1016/j.pscychresns.2005.02.001.

Abstract

Tourette syndrome (TS) is hypothesised to be caused by an abnormal organization of movement control. The aim of this study was to use functional magnetic resonance imaging to study motor cortex activation in a TS patient. Usual and unusual self-paced voluntary movements were performed. The TS patient displayed supplementary motor area (SMA) activation during both tasks. This activation reflects a continuous use of the SMA to perform the voluntary motor movements required in both tasks. Moreover, the absence of tics during the execution of these voluntary motor tasks suggests that tic activity may be suppressed by additional mental effort.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Basal Ganglia / pathology
  • Brain / anatomy & histology*
  • Cerebral Cortex / pathology
  • Corpus Striatum / pathology
  • Humans
  • Magnetic Resonance Imaging*
  • Male
  • Motor Cortex / pathology*
  • Movement Disorders / etiology*
  • Movement Disorders / physiopathology
  • Nerve Net / physiopathology
  • Thalamus / pathology
  • Tourette Syndrome / complications*
  • Tourette Syndrome / pathology*
  • Tourette Syndrome / physiopathology
  • Volition*