Abstract
A growing number of systemic inflammatory diseases characterized in part by recurrent fevers, leukocytosis, anemia, and elevated acute phase proteins are linked to interleukin (IL)-1 activity since rapid and sustained resolution is observed upon specific blockade of IL-1 receptors. Rapid resolution of systemic and local inflammation is now also reported in systemic onset juvenile idiopathic arthritis (SoJIA). Loss of control of the secretion of IL-1beta might be a common mechanism explaining the aberrant activity of IL-1 in these diseases.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Arthritis, Juvenile / drug therapy
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Arthritis, Juvenile / etiology
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Arthritis, Juvenile / metabolism*
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Humans
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Inflammation / etiology
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Inflammation / metabolism*
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Interleukin 1 Receptor Antagonist Protein
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Interleukin-1 / metabolism*
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Models, Biological*
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Receptors, Interleukin-1 / antagonists & inhibitors*
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Sialoglycoproteins / metabolism
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Sialoglycoproteins / therapeutic use
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Tumor Necrosis Factor-alpha / metabolism
Substances
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IL1RN protein, human
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Interleukin 1 Receptor Antagonist Protein
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Interleukin-1
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Receptors, Interleukin-1
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Sialoglycoproteins
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Tumor Necrosis Factor-alpha