Abstract
Camptothecin (CPT) drugs exhibit antineoplastic activity against colorectal, breast, lung and ovarian cancers. This review briefly summarizes the pharmacology of CPT drugs, examines four strategies and methods for the synthesis of camptothecins, and finally discusses homocamptothecins and silatecans, two new classes of CPT analog.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
Antineoplastic Agents, Phytogenic / chemical synthesis
-
Antineoplastic Agents, Phytogenic / pharmacology*
-
Camptothecin / analogs & derivatives*
-
Camptothecin / chemical synthesis
-
Camptothecin / pharmacology*
-
Humans
-
Organosilicon Compounds / chemical synthesis
-
Organosilicon Compounds / pharmacology
Substances
-
Antineoplastic Agents, Phytogenic
-
Organosilicon Compounds
-
homocamptothecin
-
Camptothecin