The effect of ketoconazole on the pharmacokinetics of a selective alpha 1A-adrenoceptor antagonist

J Clin Pharmacol. 2005 Jun;45(6):699-703. doi: 10.1177/0091270005275289.
No abstract available

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Adrenergic alpha-1 Receptor Antagonists*
  • Adult
  • Area Under Curve
  • Carbon Radioisotopes
  • Coumarins / pharmacology
  • Cross-Over Studies
  • Cytochrome P-450 CYP3A
  • Cytochrome P-450 Enzyme Inhibitors
  • Cytochrome P-450 Enzyme System / genetics
  • Cytochrome P-450 Enzyme System / metabolism
  • Double-Blind Method
  • Drug Administration Schedule
  • Drug Therapy, Combination
  • Fomepizole
  • Half-Life
  • Humans
  • Ketoconazole / administration & dosage
  • Ketoconazole / pharmacokinetics
  • Ketoconazole / therapeutic use*
  • Male
  • Microsomes, Liver / drug effects
  • Microsomes, Liver / metabolism
  • Pyrazoles / pharmacology
  • Pyrimidinones / analysis
  • Pyrimidinones / metabolism
  • Pyrimidinones / pharmacology
  • Quinidine / pharmacology
  • Receptors, Adrenergic, alpha-1 / administration & dosage
  • Receptors, Adrenergic, alpha-1 / therapeutic use*
  • Sulfaphenazole / pharmacology
  • Theophylline / analogs & derivatives
  • Theophylline / pharmacology

Substances

  • Adrenergic alpha-1 Receptor Antagonists
  • Carbon Radioisotopes
  • Coumarins
  • Cytochrome P-450 Enzyme Inhibitors
  • Pyrazoles
  • Pyrimidinones
  • Receptors, Adrenergic, alpha-1
  • Sulfaphenazole
  • Fomepizole
  • Cytochrome P-450 Enzyme System
  • coumarin
  • Theophylline
  • furafylline
  • CYP3A protein, human
  • Cytochrome P-450 CYP3A
  • Quinidine
  • L 771688
  • Ketoconazole