20 cases of amitriptyline poisoning have been reported. The main symptoms were come in different degrees, pupil dilatation, tachycardia, retention of urine. Raising of blood pressure and subnormality of body temperature appeared in part of patients. There were convulsive attacks in some severe patients. EKG were abnormal in half of patients. Besides gastric lavage and acceleration of excretion, using of physostigmine was one of the important reused steps, it often was the determinate factor to get success. Convulsive attack was the main dangerous to death. Some discussions have been made about relative problems.