Abstract
Whether the addition of rituximab to fludarabine and cyclosphosphamide (FC) increases early or late infection risk remains poorly defined. This retrospective analysis of 160 patients treated with FC+/-rituximab found no evidence of increased infection among patients receiving FC+rituximab, providing some evidence of safety for the continued exploration of this regimen.
Publication types
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Comparative Study
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Antibodies, Monoclonal / administration & dosage
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Antibodies, Monoclonal / adverse effects*
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Antibodies, Monoclonal, Murine-Derived
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Antineoplastic Combined Chemotherapy Protocols / adverse effects*
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Cohort Studies
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Cyclophosphamide / administration & dosage
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Cyclophosphamide / adverse effects*
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Disease Susceptibility
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Female
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Herpesviridae Infections / epidemiology
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Herpesviridae Infections / etiology
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Humans
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Immunocompromised Host
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Infections / epidemiology
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Infections / etiology*
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Leukemia, Lymphocytic, Chronic, B-Cell / complications
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Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy*
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Lymphoma, Non-Hodgkin / complications
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Lymphoma, Non-Hodgkin / drug therapy*
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Male
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Middle Aged
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Pneumonia, Pneumocystis / epidemiology
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Pneumonia, Pneumocystis / etiology
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Risk
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Rituximab
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Vidarabine / administration & dosage
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Vidarabine / adverse effects
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Vidarabine / analogs & derivatives*
Substances
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Antibodies, Monoclonal
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Antibodies, Monoclonal, Murine-Derived
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Rituximab
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Cyclophosphamide
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Vidarabine
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fludarabine