A supramolecular approach to multivalent target-specific MRI contrast agents for angiogenesis

Anouk Dirksen; Sander Langereis; Bas F M de Waal; Marcel H P van Genderen; Tilman M Hackeng; E W Meijer

doi:10.1039/b502347e

A supramolecular approach to multivalent target-specific MRI contrast agents for angiogenesis

Chem Commun (Camb). 2005 Jun 14:(22):2811-3. doi: 10.1039/b502347e. Epub 2005 Apr 14.

Authors

Anouk Dirksen¹, Sander Langereis, Bas F M de Waal, Marcel H P van Genderen, Tilman M Hackeng, E W Meijer

Affiliation

¹ Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, Eindhoven, The Netherlands.

PMID: 15928766
DOI: 10.1039/b502347e

Abstract

The synthesis of a cyclic peptide-Gd(III)DTPA molecule equipped with biotin is presented, yielding a well-defined multivalent MRI contrast agent after its coupling to avidin.

MeSH terms

Avidin / chemistry
Biotin / chemistry
Contrast Media / chemistry*
Magnetic Resonance Imaging / methods*
Models, Molecular
Molecular Structure
Neovascularization, Physiologic*
Titrimetry

Substances

Contrast Media
Avidin
Biotin