Antitumor activity of crude extract and fractions from root tuber of Cynanchum auriculatum Royle ex Wight

Phytother Res. 2005 Mar;19(3):259-61. doi: 10.1002/ptr.1678.

Abstract

Antitumor activity of the ethanol extract from the root tuber of Cynanchum auriculatum Royle ex Wight and four fractions of the ethanol extract were investigated, both in vitro and in vivo. The five samples exhibited cytotoxic activity on human tumor cell lines K562, SHG44, HCT-8, A549, PC3, in vitro and inhibition in mouse implanted sarcoma S180, in vivo. Among the five samples, fraction E was noted to be of the highest antitumor activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / administration & dosage
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Antineoplastic Agents, Phytogenic / therapeutic use
  • Cell Line, Tumor / drug effects
  • Cynanchum*
  • Dose-Response Relationship, Drug
  • Humans
  • Mice
  • Phytotherapy*
  • Plant Extracts / administration & dosage
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Plant Roots
  • Sarcoma 180 / pathology

Substances

  • Antineoplastic Agents, Phytogenic
  • Plant Extracts