Discordant molecular characterization results in a Mycobacterium avium complex strain isolated from an AIDS patient

J Med Microbiol. 2005 Jul;54(Pt 7):681-683. doi: 10.1099/jmm.0.45802-0.

Abstract

This report describes an unusual strain of Mycobacterium avium complex isolated from the sputum of an immunocompromised AIDS patient, which did not react with the MAC probe of the BDProbe Tec system, but was identified as Mycobacterium intracellulare by 16S rRNA gene sequencing. Its PCR restriction-enzyme analysis pattern was compatible with an allelic variant of M. avium. It was scotochromogenic, slow-growing and phenotypically identified as Mycobacterium scrofulaceum. Its clinical significance is not certain.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acquired Immunodeficiency Syndrome / complications*
  • Acquired Immunodeficiency Syndrome / microbiology
  • Adult
  • DNA, Bacterial / chemistry
  • DNA, Ribosomal / chemistry
  • Diagnosis, Differential
  • Humans
  • Male
  • Mycobacterium avium Complex / classification*
  • Mycobacterium avium Complex / genetics
  • Mycobacterium avium Complex / isolation & purification
  • Mycobacterium avium-intracellulare Infection / diagnosis
  • Mycobacterium avium-intracellulare Infection / microbiology*
  • Mycobacterium scrofulaceum / classification
  • Mycobacterium scrofulaceum / genetics
  • Mycobacterium scrofulaceum / isolation & purification
  • Phenotype
  • Polymerase Chain Reaction
  • RNA, Bacterial / genetics
  • RNA, Ribosomal, 16S / genetics
  • Restriction Mapping
  • Sputum / microbiology

Substances

  • DNA, Bacterial
  • DNA, Ribosomal
  • RNA, Bacterial
  • RNA, Ribosomal, 16S