A novel and simple method to replicate biological organizations (cotton and pollen grains) with high precision was proposed, in which the precursor dissolved in supercritical CO2 reacted with the surface active groups and adsorbed surface water on biological templates, followed by in situ SCF extraction of the byproducts and unreacted precursor, resulting in inorganic replicas faithfully copying both the macro- and microstructures of the biotemplates.