Abstract
[structure: see text] Analysis of the fermentation broth of a strain of the marine actinomycete Salinispora tropica has led to the isolation of two unprecedented macrolides, sporolides A (1) and B (2). The structures and absolute stereochemistries of both metabolites were elucidated using a combination of NMR spectroscopy and X-ray crystallography.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Actinobacteria / chemistry*
-
Crystallography, X-Ray
-
Enterococcus faecium / drug effects
-
Humans
-
Macrolides / chemistry*
-
Macrolides / isolation & purification*
-
Macrolides / pharmacology
-
Marine Biology
-
Methicillin Resistance / drug effects
-
Molecular Structure
-
Nuclear Magnetic Resonance, Biomolecular
-
Staphylococcus aureus / drug effects
-
Tumor Cells, Cultured
-
Vancomycin Resistance / drug effects