CONREAL web server: identification and visualization of conserved transcription factor binding sites

Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W447-50. doi: 10.1093/nar/gki378.

Abstract

The use of orthologous sequences and phylogenetic footprinting approaches have become popular for the recognition of conserved and potentially functional sequences. Several algorithms have been developed for the identification of conserved transcription factor binding sites (TFBSs), which are characterized by their relatively short and degenerative recognition sequences. The CONREAL (conserved regulatory elements anchored alignment) web server provides a versatile interface to CONREAL-, LAGAN-, BLASTZ- and AVID-based predictions of conserved TFBSs in orthologous promoters. Comparative analysis using different algorithms can be started by keyword without any prior sequence retrieval. The interface is available at http://conreal.niob.knaw.nl.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms*
  • Base Sequence
  • Binding Sites
  • Computer Graphics
  • Conserved Sequence
  • Gene Expression Regulation*
  • Internet
  • Promoter Regions, Genetic*
  • Sequence Analysis, DNA / methods*
  • Software*
  • Transcription Factors / metabolism*
  • User-Computer Interface

Substances

  • Transcription Factors