Abstract
Archaeal histone-encoding genes have been identified in marine Crenarchaea. The protein encoded by a representative of these genes, synthesized in vitro and expressed in Escherichia coli, binds DNA and forms complexes with properties typical of an archaeal histone. The discovery of histones in Crenarchaea supports the argument that histones evolved before the divergence of Archaea and Eukarya.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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DNA-Binding Proteins
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Escherichia coli / metabolism
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Genes, Archaeal
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Histones / genetics*
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Histones / metabolism
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Marine Biology
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Models, Molecular
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Molecular Sequence Data
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Phylogeny
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Recombinant Proteins / metabolism
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Sequence Alignment
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Sulfolobus / genetics*
Substances
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DNA-Binding Proteins
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Histones
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Recombinant Proteins