Polymorphisms in the DBH and DRD2 gene regions and smoking behavior

Eur Arch Psychiatry Clin Neurosci. 2006 Mar;256(2):93-7. doi: 10.1007/s00406-005-0610-x. Epub 2005 Jul 21.

Abstract

The DRD2 TaqI A and DBH-1021 C/T polymorphisms were genotyped in smoking alcoholics (N = 100), non-alcoholic smokers (N = 120) and nonsmoking controls (N = 112). Alcoholic and non-alcoholic smokers presented a higher frequency of the DRD2 TaqI A1 allele (P = 0.04) than non-smoking controls. Individuals who had at least one DBH-1021 T allele smoked fewer cigarettes per day than CC homozygotes (P = 0.03). These results are coherent with the expected effects of these polymorphisms on dopaminergic function.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alcoholism / genetics
  • Alleles
  • Chromosomes, Human, Pair 11 / genetics
  • Chromosomes, Human, Pair 9 / genetics
  • Comorbidity
  • Dopamine beta-Hydroxylase / genetics*
  • Gene Frequency
  • Genotype
  • Homozygote
  • Humans
  • Male
  • Polymerase Chain Reaction
  • Polymorphism, Genetic / genetics*
  • Receptors, Dopamine D2 / genetics*
  • Smoking / genetics*
  • Taq Polymerase / genetics

Substances

  • Receptors, Dopamine D2
  • Dopamine beta-Hydroxylase
  • Taq Polymerase