'O-Acyl isopeptide method' for the efficient preparation of amyloid beta peptide 1-42 mutants

Youhei Sohma; Yousuke Chiyomori; Maiko Kimura; Fukue Fukao; Atsuhiko Taniguchi; Yoshio Hayashi; Tooru Kimura; Yoshiaki Kiso

doi:10.1016/j.bmc.2005.06.037

'O-Acyl isopeptide method' for the efficient preparation of amyloid beta peptide 1-42 mutants

Bioorg Med Chem. 2005 Nov 15;13(22):6167-74. doi: 10.1016/j.bmc.2005.06.037.

Authors

Youhei Sohma¹, Yousuke Chiyomori, Maiko Kimura, Fukue Fukao, Atsuhiko Taniguchi, Yoshio Hayashi, Tooru Kimura, Yoshiaki Kiso

Affiliation

¹ Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science, 21st Century COE Program, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412, Japan.

PMID: 16040249
DOI: 10.1016/j.bmc.2005.06.037

Abstract

Novel water-soluble isopeptides of Abeta1-42 mutants, '26-O-acyl isoAbeta1-42 (26-AIAbeta42) mutants', which were efficiently converted to intact Abeta1-42 mutants with no byproduct formation under physiological conditions, were synthesized. These isopeptides provide a new system useful for investigating the biological function of Abeta1-42 mutants.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acylation
Amino Acid Sequence
Amino Acid Substitution
Amyloid beta-Peptides / chemical synthesis*
Amyloid beta-Peptides / genetics
Molecular Sequence Data
Mutation
Peptide Fragments / chemical synthesis*
Peptide Fragments / genetics
Solubility
Time Factors
Water / chemistry

Substances

Amyloid beta-Peptides
Peptide Fragments
amyloid beta-protein (1-42)
Water