Abstract
Pathologic diagnoses in frontotemporal lobar degeneration (FTLD) include tau-positive FTLD and tau-negative FTLD. Two variants of tau-negative FTLD are FTLD with motor neuron disease (FTLD-MND) and FTLD with motor neuron disease type inclusions but without motor neuron disease (FTLD-U). An analysis of patient outcomes in these cases reveals that FTLD-MND has significantly shorter survival than FTLD-U, suggesting that FTLD-MND is a more aggressive disease process.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Age of Onset
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Aged
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Aged, 80 and over
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Biomarkers
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Brain / pathology
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Brain / physiopathology
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Comorbidity
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Dementia / classification
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Dementia / mortality*
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Dementia / pathology*
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Female
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Humans
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Immunohistochemistry
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Inclusion Bodies / metabolism
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Inclusion Bodies / pathology
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Male
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Middle Aged
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Motor Neuron Disease / classification
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Motor Neuron Disease / mortality*
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Motor Neuron Disease / pathology*
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Motor Neurons / metabolism
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Motor Neurons / pathology
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Nerve Tissue Proteins / metabolism
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Retrospective Studies
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Sex Factors
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Spinal Cord / pathology
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Spinal Cord / physiopathology
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Survival Rate / trends
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tau Proteins / metabolism*
Substances
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Biomarkers
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Nerve Tissue Proteins
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tau Proteins