Abstract
A new flavone named miliufavol [8-(2-hydroxybenzyl)-5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,7-dimethoxy-4H-chromen-4-one or 8-C-(o)-hydroxybenzylpachypodol] from Miliusa balansae (Annonaceae) was isolated and structurally elucidated by spectroscopic means besides four known flavones: ombuine, chrysosplenol B, pachypodol and chrysosplenol C. These flavonoids exhibited interesting cytotoxic activity against three human cell lines (KB, Hep-G2, RD) with IC50 values < 5 microg/ml.
MeSH terms
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Annonaceae / chemistry*
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Antineoplastic Agents, Phytogenic / biosynthesis
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Cell Line, Tumor
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Drug Screening Assays, Antitumor
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Enzyme-Linked Immunosorbent Assay
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Flavones / biosynthesis
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Flavones / isolation & purification
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Flavones / pharmacology*
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Humans
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Magnetic Resonance Spectroscopy
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Plant Leaves / chemistry
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Spectrometry, Mass, Electrospray Ionization
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Spectroscopy, Fourier Transform Infrared
Substances
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Antineoplastic Agents, Phytogenic
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Flavones
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miliufavol