Pictet-Spengler reactions in multiphasic supercritical carbon dioxide/CO2-expanded liquid media. In situ generation of carbamates as a strategy for reactions of amines in supercritical carbon dioxide

Joshua R Dunetz; Rocco P Ciccolini; Morgan Fröling; Scott M Paap; Andrew J Allen; Andrew B Holmes; Jefferson W Tester; Rick L Danheiser

doi:10.1039/b508151c

Pictet-Spengler reactions in multiphasic supercritical carbon dioxide/CO2-expanded liquid media. In situ generation of carbamates as a strategy for reactions of amines in supercritical carbon dioxide

Chem Commun (Camb). 2005 Sep 21:(35):4465-7. doi: 10.1039/b508151c. Epub 2005 Aug 4.

Authors

Joshua R Dunetz¹, Rocco P Ciccolini, Morgan Fröling, Scott M Paap, Andrew J Allen, Andrew B Holmes, Jefferson W Tester, Rick L Danheiser

Affiliation

¹ Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

PMID: 16136252
DOI: 10.1039/b508151c

Abstract

Acyl-Pictet-Spengler cyclizations can be achieved in scCO2/CO2-expanded liquid media via the in situ formation of carbamate derivatives of beta-arylethylamines.