Abstract
Hematopoietic stem cell transplantation is an increasingly used therapy for treatment of autoimmune diseases and severe immune-mediated disorders. We address some general concepts and principles in the development of hematopoietic stem cell transplantation in order to understand the principles and design of safe autologous and allogeneic transplant regimens for these unique diseases.
MeSH terms
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Alemtuzumab
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Animals
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Antibodies, Monoclonal / therapeutic use
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Antibodies, Monoclonal, Humanized
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Antibodies, Neoplasm / therapeutic use
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Autoimmune Diseases / immunology
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Autoimmune Diseases / surgery*
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Clinical Trials as Topic
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Contraindications
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Disease Models, Animal
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Epitopes
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Forecasting
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Hematopoietic Stem Cell Transplantation* / adverse effects
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Hematopoietic Stem Cell Transplantation* / trends
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Humans
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Immune System / immunology
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Mice
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Transplantation Conditioning / adverse effects
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Transplantation Conditioning / methods
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Transplantation, Autologous
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Transplantation, Homologous
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Treatment Outcome
Substances
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Antibodies, Monoclonal
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Antibodies, Monoclonal, Humanized
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Antibodies, Neoplasm
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Epitopes
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Alemtuzumab