Abstract
The interactive effects of age and cholinergic damage were assessed behaviorally in young and middle-aged rats. Rats were lesioned at either 3 or 17 months of age by injection of 192 IgG-saporin immunotoxin into the medial septum and the nucleus basalis magnocellularis, and they were then tested on a range of behavioral tasks: a nonmatching-to-position task in a T-maze, an object-recognition task, an object-location task, and an open-field activity test. Depending on the task used, only an age or a lesion effect was observed, but there was no Age X Lesion interaction. Middle-aged and young rats responded to the cholinergic lesions in the same manner. These results show that in the middle-aged rats in which cholinergic transmission was affected, additional injury to the system was not always accompanied by major cognitive dysfunctions.
(c) 2005 APA
MeSH terms
-
Acetylcholine / metabolism*
-
Aging / physiology*
-
Analysis of Variance
-
Animals
-
Antibodies, Monoclonal / toxicity
-
Basal Nucleus of Meynert / injuries
-
Basal Nucleus of Meynert / physiopathology*
-
Behavior, Animal / drug effects
-
Behavior, Animal / physiology*
-
Body Weight / drug effects
-
Body Weight / physiology
-
Choline O-Acetyltransferase / metabolism
-
Exploratory Behavior / drug effects
-
Exploratory Behavior / physiology
-
Immunohistochemistry / methods
-
Immunotoxins / toxicity
-
Male
-
Maze Learning / drug effects
-
Motor Activity / drug effects
-
N-Glycosyl Hydrolases
-
Rats
-
Rats, Wistar
-
Recognition, Psychology / drug effects
-
Retention, Psychology / drug effects
-
Retention, Psychology / physiology
-
Ribosome Inactivating Proteins, Type 1
-
Saporins
-
Septal Nuclei / injuries
-
Septal Nuclei / physiopathology*
-
Spatial Behavior / drug effects
-
Time Factors
Substances
-
192 IgG-saporin
-
Antibodies, Monoclonal
-
Immunotoxins
-
Ribosome Inactivating Proteins, Type 1
-
Choline O-Acetyltransferase
-
N-Glycosyl Hydrolases
-
Saporins
-
Acetylcholine