Abstract
We evaluated the efficacy of nanoparticle-encapsulated antituberculosis drugs administered every 10 days versus that of daily nonencapsulated drugs against Mycobacterium tuberculosis aerosol infection in guinea pigs. Both treatments significantly reduced the bacterial count and lung histopathology, suggesting that the nanoparticle drug delivery system has potential in intermitted treatment of tuberculosis.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Administration, Inhalation
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Administration, Oral
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Animals
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Antitubercular Agents / administration & dosage*
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Antitubercular Agents / therapeutic use*
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Capsules
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Drug Carriers
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Female
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Guinea Pigs
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Lung / microbiology
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Lung / pathology
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Mycobacterium tuberculosis / drug effects*
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Nanostructures*
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Tuberculosis / drug therapy*
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Tuberculosis / microbiology
Substances
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Antitubercular Agents
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Capsules
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Drug Carriers