Helicobacter pylori infection increases cell kinetics in human gastric epithelial cells without adhering to proliferating cells

Masayoshi Hayama; Yoshiyuki Kawakami; Yasunori Kaneko; Kenji Sano; Hiroyoshi Ota

doi:10.1111/j.1582-4934.2005.tb00508.x

Helicobacter pylori infection increases cell kinetics in human gastric epithelial cells without adhering to proliferating cells

J Cell Mol Med. 2005 Jul-Sep;9(3):746-7. doi: 10.1111/j.1582-4934.2005.tb00508.x.

Authors

Masayoshi Hayama¹, Yoshiyuki Kawakami, Yasunori Kaneko, Kenji Sano, Hiroyoshi Ota

Affiliation

¹ Department of Biomedical Laboratory Sciences, Shinshu University School of Medicine, Asahi 3-1-1, Matsumoto, Nagano, 390-8621, Japan. mahayama@hsp.md.shinshu-u.ac.jp

Abstract

We investigated the effect of H. pylori infection on cell proliferation of gastric mucosa using immunostaining for H. pylori or Ki67. H. pylori cells attached to surface mucous cells covering luminal surface and the upper part of gastric foveolae, and up-regulated the proliferative activity of gastric epithelial cells without adhering to the proliferating epithelial cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bacterial Adhesion*
Gastric Mucosa / microbiology
Gastric Mucosa / pathology*
Helicobacter Infections / pathology*
Helicobacter pylori* / physiology
Humans