We report two young female patients who developed sudden-onset nonpitting edema in both hands and lower legs in early autumn with no significant previous or family history. One of these patients showed arthralgia in both wrists and ankles. The clinical symptoms improved without treatment, and they were diagnosed as having nonepisodic angioedema with eosinophilia (NEAE) based on laboratory investigations and the lack of recurrence. The clinical picture of this disease is often similar to that of rheumatologic disorders with tenosynovitis with regard to edema and pain in the distal portion of the extremities. When edema is seen in the bilateral hands and lower legs, particularly in young women, NEAE should be actively considered as a possible diagnosis.