Model based prognosis of postoperative object naming in left temporal lobe epilepsy

Seizure. 2005 Dec;14(8):562-8. doi: 10.1016/j.seizure.2005.09.001. Epub 2005 Oct 19.

Abstract

Epilepsy surgery in the left temporal lobe is associated with a high risk of naming decline. In the present study, in 45 patients with left temporal lobe epilepsy (TLE) and confirmed left hemisphere language dominance, 13 (29%) patients demonstrated postoperative decrement >or=5 naming failures in the Boston Naming Test (BNT). Multivariate discriminant analysis with age at onset of epilepsy, age at first risk, age at operation and preoperative naming performance as predictors indicated that 12 (92%) patients with later naming decline could be identified preoperatively. Univariate group comparisons revealed that specifically patients with seizure onset later than 14 years without preceding risk factors (e.g., febrile seizures) are in danger of postoperative dysnomia. It is hypothesized, that there is a strong connection between stable naming performance and deviant intrahemispheric speech representation as a result of early brain damage and/or chronic seizures.

Publication types

  • Clinical Trial
  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anomia / etiology*
  • Epilepsy, Temporal Lobe* / diagnosis
  • Epilepsy, Temporal Lobe* / physiopathology
  • Epilepsy, Temporal Lobe* / surgery
  • Female
  • Functional Laterality
  • Humans
  • Male
  • Middle Aged
  • Models, Biological
  • Multivariate Analysis
  • Neuropsychological Tests / statistics & numerical data
  • Postoperative Period
  • Prognosis
  • Psychosurgery / adverse effects*
  • Psychosurgery / methods