Efficacy and safety of the covered Wallstent in patients with distal malignant biliary obstruction

Gastrointest Endosc. 2005 Nov;62(5):742-8. doi: 10.1016/j.gie.2005.06.030.

Abstract

Background: The aim of this study was to evaluate the efficacy and the safety of the covered Wallstent, a commercially available silicone-covered, self-expandable metallic stent (covered Wallstent), for the treatment of distal malignant biliary obstruction.

Methods: Sixty-nine consecutive patients with unresectable distal malignant biliary obstruction who underwent covered Wallstent placement between October 2001 and October 2003 were studied at 4 affiliated hospitals.

Results: Mean stent patency and mean survival were 139.1 days and 200.9 days, respectively. Stent occlusion occurred in 7 cases (10.1%), but tumor ingrowth was not observed. Seventeen complications, including 5 cholangitis (7.2%), 4 stent migration (5.8%), 4 cholecystitis (5.8%), and 4 pancreatitis (5.8%) were observed in 16 patients (23.2%). Stent misplacement was observed in 7 patients (10.1%).

Conclusions: Covered Wallstent is effective in preventing tumor ingrowth for the treatment of distal malignant biliary obstruction. However, the overall complication rate may be higher than uncovered self-expanding metal stents and covered self-expanding metal stents of different design.

Publication types

  • Multicenter Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Biliary Tract Neoplasms / complications*
  • Cholestasis, Extrahepatic / etiology
  • Cholestasis, Extrahepatic / surgery*
  • Coated Materials, Biocompatible
  • Common Bile Duct Diseases / etiology
  • Common Bile Duct Diseases / surgery*
  • Endoscopy, Digestive System
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pancreatic Neoplasms / complications*
  • Silicones
  • Stents* / adverse effects

Substances

  • Coated Materials, Biocompatible
  • Silicones