Synthesis and study of conformationally restricted 3'-deoxy-3',4'-exo-methylene nucleoside analogues

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):383-5. doi: 10.1081/ncn-200059796.

Abstract

Hitherto unknown restricted 3'-deoxy-3',4'-exo-methylene nucleoside derivatives bearing the nucleic acid naturally occurring pyrimidine bases have been synthesized. The compounds were tested for their activity against HIV, HBV, and several RNA viruses, but they did not show significant antiviral effect.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / pharmacology
  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / pharmacology
  • HIV / metabolism
  • HIV Infections / drug therapy
  • Hepatitis B / drug therapy
  • Hepatitis B virus / metabolism
  • Hydrocarbons / chemical synthesis
  • Hydrocarbons / chemistry
  • In Vitro Techniques
  • Methane / analogs & derivatives*
  • Methane / chemical synthesis
  • Methane / chemistry
  • Models, Chemical
  • Nucleic Acid Conformation*
  • Nucleosides / chemical synthesis*
  • Nucleosides / chemistry
  • RNA Viruses / metabolism
  • Virus Replication / drug effects

Substances

  • Anti-HIV Agents
  • Antiviral Agents
  • Hydrocarbons
  • Nucleosides
  • carbene
  • Methane