Primary care for HIV-infected patients includes ensuring that eligible patients receive hepatitis B and A virus vaccinations, all women undergo appropriate screening and follow-up for cervical cytologic abnormalities, and all patients undergo routine screening for renal function abnormalities. Current guidelines in these specific areas of HIV primary care are reviewed. This article summarizes a presentation on issues in primary care for HIV-infected patients by David H. Spach, MD, at the 8th Annual Clinical Conference for Ryan white CARE Act clinicians in New Orleans in June 2005.