Long term morbidity of neoadjuvant chemoradiation for pancreatic head adenocarcinoma

Eur J Surg Oncol. 2006 Feb;32(1):77-9. doi: 10.1016/j.ejso.2005.10.004. Epub 2005 Nov 21.

Abstract

Purpose: To report the long term risks of neoadjuvant chemoradiation (NCRT) after duodenopancreatectomy (DP) for adenocarcinoma of the head of pancreas.

Methods: Between January 1996 and December 2002, 26 patients with biopsy-proven adenocarcinoma of the head of pancreas were treated by this combination of therapies.

Results: Two patients had delayed NCRT-related small bowel infarction: one died from superior mesenteric artery stenosis 36 months after DP without recurrence at laparotomy; there was one limited infarction 16 months after DP.

Conclusions: Long term vascular morbidity after NCRT is significant.

Publication types

  • Comparative Study

MeSH terms

  • Adenocarcinoma / drug therapy
  • Adenocarcinoma / epidemiology*
  • Adenocarcinoma / radiotherapy
  • Antineoplastic Agents / therapeutic use
  • Biopsy
  • Follow-Up Studies
  • Humans
  • Morbidity
  • Neoadjuvant Therapy
  • Pancreas / diagnostic imaging
  • Pancreas / pathology
  • Pancreatic Neoplasms / drug therapy
  • Pancreatic Neoplasms / epidemiology*
  • Pancreatic Neoplasms / radiotherapy
  • Pancreaticoduodenectomy
  • Retrospective Studies
  • Survival Rate
  • Time Factors
  • Treatment Outcome
  • Ultrasonography

Substances

  • Antineoplastic Agents