Catalytic enantioselective Conia-ene reaction

J Am Chem Soc. 2005 Dec 14;127(49):17168-9. doi: 10.1021/ja055059q.

Abstract

An enantioselective intramolecular Conia-ene reaction of beta-dicarbonyl compounds and alkynes to afford methylene cyclopentanes is described. The reaction employs a DTBMSegphos-Pd(II)/Yb(III) dual catalyst system that allows for the asymmetric synthesis of all-carbon quaternary centers and generates a product containing an alkene that can be further manipulated.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Heterocyclic Compounds / chemistry*
  • Models, Chemical
  • Models, Molecular
  • Molecular Structure
  • Stereoisomerism

Substances

  • Heterocyclic Compounds