Frequency of chromosomal aneuploidies and deletions of the RB and TP53 genes in MALT lymphomas harboring the t(14;18)(q32;q21)

Eva Maria Murga Penas; Kristina Hinz; Laura Biller; Tijana Zivkovic; Kerstin Röser; Thomas Löning; Reza Parwaresch; Carsten Bokemeyer; Judith Dierlamm

doi:10.1016/j.cancergencyto.2005.06.012

Frequency of chromosomal aneuploidies and deletions of the RB and TP53 genes in MALT lymphomas harboring the t(14;18)(q32;q21)

Cancer Genet Cytogenet. 2006 Jan 1;164(1):81-3. doi: 10.1016/j.cancergencyto.2005.06.012.

Authors

Eva Maria Murga Penas¹, Kristina Hinz, Laura Biller, Tijana Zivkovic, Kerstin Röser, Thomas Löning, Reza Parwaresch, Carsten Bokemeyer, Judith Dierlamm

Affiliation

¹ Department of Oncology and Hematology, University Hospital Hamburg-Eppendorf, Germany.

PMID: 16364768
DOI: 10.1016/j.cancergencyto.2005.06.012

Abstract

The t(14;18)(q32;q21) involving the MALT1/MLT and IGH genes has been identified recently as a recurrent abnormality in mucosa-associated lymphoid tissue (MALT) lymphomas. The frequency of secondary chromosomal aberrations in MALT lymphomas harboring the t(14;18) is largely unknown. We therefore analyzed six t(14;18)-positive MALT lymphomas (five parotid, one conjunctiva) by interphase fluorescence in situ hybridization for aneuploidies of chromosomes 3, 7, 12, 18, and X, gains or disruption of the CMYC/8q24 and BCL6/3q27 genes, as well as deletions of the retinoblastoma and TP53 tumor suppressor genes. Except for one MALT lymphoma of the parotid with trisomy 3, neither aneuploidies nor deletions were detected in any of our cases.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aneuploidy*
Chromosomes, Human, Pair 14*
Chromosomes, Human, Pair 18*
Chromosomes, Human, Pair 3
Gene Deletion*
Genes, Retinoblastoma*
Genes, p53*
Humans
Lymphoma, B-Cell, Marginal Zone / genetics*
Translocation, Genetic*
Trisomy