Abstract
Plasmodium vivax apical membrane antigen 1, an important malaria vaccine candidate, was immunogenic during natural malaria infections in Sri Lanka, where low transmission and unstable malaria conditions prevail. Antibody prevalence increased with exposure in areas where malaria was or was not endemic. A marked isotype switch to cytophilic (immunoglobulin G1 [IgG1]/IgG3) antibodies was evident with increasing exposure exclusively in residents from areas of endemicity.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Antibodies, Protozoan / biosynthesis*
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Antigens, Protozoan / immunology*
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Humans
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Immunoglobulin G / biosynthesis
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Malaria, Vivax / epidemiology
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Malaria, Vivax / immunology*
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Membrane Proteins / immunology*
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Plasmodium vivax / immunology*
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Protozoan Proteins / immunology*
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Sri Lanka / epidemiology
Substances
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Antibodies, Protozoan
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Antigens, Protozoan
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Immunoglobulin G
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Membrane Proteins
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Protozoan Proteins
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apical membrane antigen I, Plasmodium