Antiviral properties of ent-labdene diterpenes of Andrographis paniculata nees, inhibitors of herpes simplex virus type 1

Phytother Res. 2005 Dec;19(12):1069-70. doi: 10.1002/ptr.1765.

Abstract

Andrographolide, neoandrographolide and 14-deoxy-11,12-didehydroandrographolide, ent-labdene diterpenes isolated from Andrographis paniculata showed viricidal activity against herpes simplex virus 1 (HSV-1). None of these compounds exhibited significant cytotoxicity at viricidal concentrations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Andrographis*
  • Animals
  • Antiviral Agents / pharmacology*
  • Chlorocebus aethiops
  • Diterpenes / pharmacology
  • Glucosides / pharmacology
  • Herpesvirus 1, Human / drug effects*
  • Plant Extracts / pharmacology*
  • Plant Leaves
  • Tetrahydronaphthalenes / pharmacology
  • Vero Cells

Substances

  • Antiviral Agents
  • Diterpenes
  • Glucosides
  • Plant Extracts
  • Tetrahydronaphthalenes
  • andrographolide
  • neoandrographolide