Abstract
The interaction of the natural alkaloid berberine with various G-quadruplex DNA structures and its ability to inhibit telomerase have been examined and compared with those of a synthetic piperidino derivative and the related compound coralyne. The results show that these molecules have selectivity for G-quadruplex compared to duplex DNA, and that their aromatic moieties play a dominant role in quadruplex binding.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / metabolism*
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Berberine Alkaloids / chemical synthesis*
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Berberine Alkaloids / metabolism*
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DNA / metabolism*
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Humans
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Intercalating Agents / metabolism
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Ligands
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Nucleic Acid Denaturation
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Nucleic Acid Heteroduplexes / chemistry*
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Nucleic Acid Heteroduplexes / metabolism
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Piperidines / chemistry
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Piperidines / metabolism
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Telomerase / antagonists & inhibitors*
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Telomere / drug effects*
Substances
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Antineoplastic Agents
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Berberine Alkaloids
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Intercalating Agents
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Ligands
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Nucleic Acid Heteroduplexes
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Piperidines
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piperidine
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coralyne
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DNA
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Telomerase