Sleep disorders are among the factors that can reduce the quality of life in patients with chronic kidney disease. Chronic kidney disease patients could benefit from an accurate evaluation and treatment of insomnia because this sleep disorder is associated with a high persistence-relapse rate, poor physical health, and mental disease (anxiety, depression) both in terms of comorbidity and antecedent. A multilayer evaluation of insomnia is possible because of valid and reliable instruments (both objective and subjective). Furthermore, a rational etiologic model of insomnia allows better understanding and treatment as a result of effective cognitive-behavioral techniques.