QSAR models of quail dietary toxicity based on the graph of atomic orbitals

Bioorg Med Chem Lett. 2006 Apr 1;16(7):1941-3. doi: 10.1016/j.bmcl.2005.12.085. Epub 2006 Jan 25.

Abstract

Graphs of atomic orbitals (GAOs) have been used to represent molecular structures. We describe rules to convert the labelled hydrogen-filled graphs (LHFGs) into GAOs. The GAO is one possible way of taking account of the structure of atoms (i.e., atomic orbitals, such as 1s(1), 2p(2) and 3d(10)) for QSPR/QSAR analyses. Optimization of correlation weights of local invariants (OCWLI) of the LHFGs and the GAOs was used to obtain a method of quail dietary toxicity modelling. Statistical characteristics of the models based on the OCWLI of GAO are better than those based on the OCWLI of the LHFGs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Models, Theoretical*
  • Monte Carlo Method
  • Pesticides / chemistry
  • Pesticides / toxicity
  • Quail
  • Quantitative Structure-Activity Relationship
  • Toxicity Tests*

Substances

  • Pesticides