Dibutyryl-cAMP induces SNAP-25 translocation into the neurites in PC12

Brain Res Dev Brain Res. 1991 Mar 18;59(1):104-8. doi: 10.1016/0165-3806(91)90035-h.

Abstract

SNAP-25 immunoreactivity was translocated into the endings of the processes induced in PC12 cells by dibutyryl-cAMP-treatment. Conversely, the protein was not present in the endings of the processes seen after NGF-treatment unless dibutyryl-cAMP was used simultaneously. This redistribution of SNAP-25 immunoreactivity appeared to be dependent upon new protein synthesis. Finally, dibutyryl-cAMP was capable of inducing SNAP-25 expression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adrenal Gland Neoplasms / physiopathology
  • Animals
  • Axons / drug effects
  • Axons / physiology*
  • Bucladesine / pharmacology*
  • Cell Differentiation
  • Cell Line
  • Membrane Proteins*
  • Nerve Growth Factors / pharmacology
  • Nerve Tissue Proteins / metabolism*
  • Pheochromocytoma / physiopathology
  • Synaptosomal-Associated Protein 25

Substances

  • Membrane Proteins
  • Nerve Growth Factors
  • Nerve Tissue Proteins
  • Synaptosomal-Associated Protein 25
  • Bucladesine