Translocation (13;17)(q14;q25) as a novel chromosomal abnormality in acute myeloid leukemia-M4

Nihan Turhan; Nüket Yürür-Kutlay; Pervin Topcuoglu; Müyesser Sayki; Meltem Yüksel; Günhan Gürman; Ajlan Tükün

doi:10.1016/j.leukres.2005.12.011

Translocation (13;17)(q14;q25) as a novel chromosomal abnormality in acute myeloid leukemia-M4

Leuk Res. 2006 Jul;30(7):903-5. doi: 10.1016/j.leukres.2005.12.011. Epub 2006 Feb 16.

Authors

Nihan Turhan¹, Nüket Yürür-Kutlay, Pervin Topcuoglu, Müyesser Sayki, Meltem Yüksel, Günhan Gürman, Ajlan Tükün

Affiliation

¹ Ankara University, Faculty of Medicine, Medical Genetics Department, Ankara, Turkey. tukun@medicine.ankara.edu

PMID: 16469377
DOI: 10.1016/j.leukres.2005.12.011

Abstract

We report a case of AML-M4 in which G-band karyotyping revealed a previously unreported t(13;17)(q14;q25) in metaphase preparations. The breakpoints at 13q14 and 17q25 are associated with poor prognosis. The MSF and FKHR genes are located on 17q25 and 13q14, respectively. This report of AML-M4 harboring t(13;17)(q14;q25) as a unique cytogenetic abnormality provides more data on the leukomogenesis with rearrangements related with 13q14 and 17q25.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Chromosome Aberrations*
Chromosomes, Human, Pair 13 / genetics*
Chromosomes, Human, Pair 17 / genetics*
Cytogenetic Analysis / methods
Fatal Outcome
Female
Humans
In Situ Hybridization, Fluorescence / methods
Karyotyping
Leukemia, Myelomonocytic, Acute / diagnosis
Leukemia, Myelomonocytic, Acute / drug therapy
Leukemia, Myelomonocytic, Acute / genetics*
Sensitivity and Specificity
Translocation, Genetic / genetics*