A short total synthesis of (+/-)-aspidospermidine

Org Lett. 2006 Mar 2;8(5):831-4. doi: 10.1021/ol052749q.

Abstract

A cascade radical cyclization starting from an amidyl radical has been used for the construction of (+/-)-aspidospermidine. This approach has also been developed for the preparation of a tricycle whose framework is contained in the stemona alkaloids.

MeSH terms

  • Alkaloids / chemical synthesis*
  • Alkaloids / chemistry
  • Aspidosperma / chemistry
  • Cyclization
  • Indole Alkaloids
  • Indoles / chemical synthesis*
  • Indoles / chemistry
  • Molecular Structure
  • Quinolines / chemical synthesis*
  • Quinolines / chemistry
  • Stemonaceae / chemistry
  • Stereoisomerism

Substances

  • Alkaloids
  • Indole Alkaloids
  • Indoles
  • Quinolines
  • aspidospermidine